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Albumins and their processing machinery are hijacked for cyclic peptides in sunflower.
- Source :
-
Nature chemical biology [Nat Chem Biol] 2011 May; Vol. 7 (5), pp. 257-9. Date of Electronic Publication: 2011 Mar 20. - Publication Year :
- 2011
-
Abstract
- The cyclic peptide sunflower trypsin inhibitor 1 (SFTI-1) blocks trypsin and is a promising drug lead and protein engineering scaffold. We show that SFTI-1 and the newfound SFT-L1 are buried within PawS1 and PawS2, precursors for seed storage protein albumins. Proalbumins are matured by asparaginyl endopeptidase, which we show is required to liberate both ends of SFTI-1 as well as to mature PawS1 albumin. Thus, these peptides emerge from within an albumin precursor by the action of albumin's own processing enzyme.
- Subjects :
- Albumins chemistry
Amino Acid Sequence
Cysteine Endopeptidases metabolism
Helianthus chemistry
Molecular Sequence Data
Peptides, Cyclic chemistry
Prealbumin metabolism
Seed Storage Proteins chemistry
Seed Storage Proteins metabolism
Trypsin Inhibitors chemistry
Trypsin Inhibitors pharmacology
Albumins metabolism
Helianthus metabolism
Peptides, Cyclic metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1552-4469
- Volume :
- 7
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Nature chemical biology
- Publication Type :
- Academic Journal
- Accession number :
- 21423169
- Full Text :
- https://doi.org/10.1038/nchembio.542