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Effect of toremifene on the activity of NK-cells in NZB/NZW mice.
- Source :
-
Journal of steroid biochemistry [J Steroid Biochem] 1990 Jun 22; Vol. 36 (3), pp. 207-9. - Publication Year :
- 1990
-
Abstract
- The effect of toremifene on NK-cells isolated from the spleen of NZB/NZW mice was studied in comparison to tamoxifen and estradiol. Unlike estradiol but like tamoxifen, toremifene did not influence the activity of NK-cells. Low doses (0.1 and 10.0 mg/kg) of toremifene did not suppress, but a high dose of toremifene and tamoxifen (50 mg/kg for 6 weeks) suppressed the stimulating effect of human interferon alpha on the cells.
- Subjects :
- Animals
Chromium Radioisotopes
Dose-Response Relationship, Drug
Estradiol pharmacology
Female
Humans
Interferon Type I pharmacology
Killer Cells, Natural physiology
Mice
Mice, Inbred Strains
Spleen cytology
Tamoxifen pharmacology
Time Factors
Toremifene
Estrogen Antagonists pharmacology
Killer Cells, Natural drug effects
Tamoxifen analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0022-4731
- Volume :
- 36
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of steroid biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 2142234
- Full Text :
- https://doi.org/10.1016/0022-4731(90)90006-e