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Innate control of B cell responses.
- Source :
-
Trends in immunology [Trends Immunol] 2011 May; Vol. 32 (5), pp. 202-11. Date of Electronic Publication: 2011 Mar 16. - Publication Year :
- 2011
-
Abstract
- Mature B cells generate protective immunity by undergoing immunoglobulin (Ig) class switching and somatic hypermutation, two Ig gene-diversifying processes that usually require cognate interactions with T cells that express CD40 ligand. This T cell-dependent pathway provides immunological memory but is relatively slow to occur. Thus, it must be integrated with a faster, T cell-independent pathway for B cell activation through CD40 ligand-like molecules that are released by innate immune cells in response to microbial products. Here, we discuss recent advances in our understanding of the interplay between the innate immune system and B cells, particularly at the mucosal interface. We also review the role of innate signals in the regulation of Ig diversification and production.<br /> (Copyright © 2011 Elsevier Ltd. All rights reserved.)
- Subjects :
- B-Cell Activating Factor metabolism
B-Lymphocytes cytology
Gene Expression Regulation immunology
Ligands
T-Lymphocytes immunology
T-Lymphocytes metabolism
Toll-Like Receptors metabolism
Tumor Necrosis Factor Ligand Superfamily Member 13 metabolism
B-Lymphocytes immunology
B-Lymphocytes metabolism
Genes, Immunoglobulin physiology
Immunity, Innate
Subjects
Details
- Language :
- English
- ISSN :
- 1471-4981
- Volume :
- 32
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Trends in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 21419699
- Full Text :
- https://doi.org/10.1016/j.it.2011.02.004