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A multi-centre study of therapeutic efficacy and safety of platelet components treated with amotosalen and ultraviolet A pathogen inactivation stored for 6 or 7 d prior to transfusion.
- Source :
-
British journal of haematology [Br J Haematol] 2011 May; Vol. 153 (3), pp. 393-401. Date of Electronic Publication: 2011 Mar 21. - Publication Year :
- 2011
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Abstract
- Bacteria in platelet components (PC) may result in transfusion-related sepsis (TRS). Pathogen inactivation of PC with amotosalen (A-PC) can abrogate the risk of TRS and hence facilitate storage to 7 d. A randomized, controlled, double-blinded trial to evaluate the efficacy and safety of A-PC stored for 6-7 d was conducted. Patients were randomized to receive one transfusion of conventional PC (C-PC) or A-PC stored for 6-7 d. The primary endpoint was the 1 h corrected count increment (CCI) with an acceptable inferiority of 30%. Secondary endpoints included 1- and 24-h count increment (CI), 24-h CCI, time to next PC transfusion, red blood cell (RBC) use, bleeding and adverse events. 101 and 100 patients received A-PC or C-PC respectively. The ratio of 1-h CCI (A-PC:C-PC) was 0·87 (95% confidence interval: 0·73, 1·03) demonstrating non-inferiority (P = 0·007), with respective mean 1-h CCIs of 8163 and 9383; mean 1-h CI was not significantly different. Post-transfusion bleeding and RBC use were not significantly different (P = 0·44, P = 0·82 respectively). Median time to the next PC transfusion after study PC was not significantly different between groups: (2·2 vs. 2·3 d, P = 0·72). Storage of A-PCs for 6-7 d had no impact on platelet efficacy.<br /> (© 2011 Blackwell Publishing Ltd.)
- Subjects :
- Adolescent
Adult
Aged
Blood Platelets microbiology
Blood Platelets radiation effects
Cellular Senescence
Double-Blind Method
Erythrocyte Transfusion
Female
Furocoumarins pharmacology
Hemostasis
Humans
Male
Microbial Viability
Middle Aged
Platelet Count
Platelet Transfusion adverse effects
Prospective Studies
Time Factors
Treatment Outcome
Young Adult
Blood Platelets drug effects
Blood Preservation methods
Platelet Transfusion methods
Ultraviolet Rays
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2141
- Volume :
- 153
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- British journal of haematology
- Publication Type :
- Academic Journal
- Accession number :
- 21418180
- Full Text :
- https://doi.org/10.1111/j.1365-2141.2011.08635.x