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Effect of urethan on the induction of ornithine decarboxylase in regenerating rat liver.
- Source :
-
Biochimica et biophysica acta [Biochim Biophys Acta] 1978 Dec 01; Vol. 544 (2), pp. 372-80. - Publication Year :
- 1978
-
Abstract
- The effect of urethan on the induction of ornithine decarboxylase in the early stage of the regeneration of rat liver was studied. The induced activity of ornithine decarboxylase was suppressed by administration of urethan immediately after partial hepatectomy. Although ornithine decarboxylase was induced biphasically by partial hepatectomy, a single intraperitoneal injection of urethan resulted in the reduction of both phases. However, the ornithine decarboxylase activity induced by glucocorticoids and growth hormone was not suppressed by urethan. The increased level of 3',5'-cyclic adenosine monophosphate induced by partial hepatectomy was also reduced by urethan and this suppression was proportional to the suppression of ornithine decarboxylase activity. Reversal of the urethan-induced suppression of ornithine decarboxylase by administration of dibutyryl 3',5'-cyclic adenosine monophosphate was also observed.
- Subjects :
- Animals
Cortisone pharmacology
Cyclic AMP metabolism
Dexamethasone pharmacology
Enzyme Induction drug effects
Growth Hormone pharmacology
Kinetics
Liver drug effects
Liver metabolism
Male
Rats
Carboxy-Lyases biosynthesis
Liver enzymology
Liver Regeneration drug effects
Ornithine Decarboxylase biosynthesis
Urethane pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0006-3002
- Volume :
- 544
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Biochimica et biophysica acta
- Publication Type :
- Academic Journal
- Accession number :
- 214156
- Full Text :
- https://doi.org/10.1016/0304-4165(78)90105-8