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A prospective study of inflammation markers and endometrial cancer risk in postmenopausal hormone nonusers.
- Source :
-
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2011 May; Vol. 20 (5), pp. 971-7. Date of Electronic Publication: 2011 Mar 17. - Publication Year :
- 2011
-
Abstract
- Background: It is hypothesized that inflammation may mediate the relationship between obesity and endometrial cancer risk. We examined the associations of three inflammation markers, C-reactive protein (CRP), interleukin (IL)-6 and tumor necrosis factor (TNF)-α, with risk of endometrial cancer.<br />Methods: A case-cohort study was nested within the Women's Health Initiative, a cohort of postmenopausal women. Baseline plasma samples of 151 incident endometrial cancer cases and 301 subcohort subjects not using hormones were assayed.<br />Results: CRP, but not IL-6 or TNF-α, was positively associated with endometrial cancer risk after adjusting for age and BMI [HR comparing extreme quartiles (HR q(4)-q(1)) = 2.29; 95% CI = 1.13-4.65; P(trend) = 0.012). After additional adjustment for estradiol and insulin, this association was attenuated (HRq(4)-q(1) = 1.70; 95% CI = 0.78-3.68; P(trend) = 0.127). Obesity (BMI ≥ 30 kg/m(2)) was associated with endometrial cancer risk in an age-adjusted model. The obesity effect was reduced by 48%, 67%, and 77% when either estradiol, CRP, or insulin, respectively, was included in the model, and it became null when all three factors were adjusted for simultaneously.<br />Conclusions: The association between inflammation, as indicated by a relatively high level of CRP, and endometrial cancer risk may partially be explained by hyperinsulinemia and elevated estradiol. Nevertheless, all three factors contribute to and mediate the link between obesity and endometrial cancer in postmenopausal women not using hormones.<br />Impact: The association between obesity and endometrial cancer risk in postmenopausal women may be attributed to inflammation, insulin resistance, and elevated estrogen.<br /> (©2011 AACR.)
- Subjects :
- Aged
Case-Control Studies
Cohort Studies
Endometrial Neoplasms diagnosis
Endometrial Neoplasms etiology
Endometrium metabolism
Female
Follow-Up Studies
Humans
Hyperinsulinism blood
Hyperinsulinism diagnosis
Middle Aged
Prognosis
Prospective Studies
Risk Factors
Biomarkers, Tumor blood
C-Reactive Protein metabolism
Endometrial Neoplasms blood
Inflammation blood
Interleukin-6 blood
Postmenopause blood
Tumor Necrosis Factor-alpha blood
Subjects
Details
- Language :
- English
- ISSN :
- 1538-7755
- Volume :
- 20
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 21415362
- Full Text :
- https://doi.org/10.1158/1055-9965.EPI-10-1222