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Enhanced inactivation of bacteria by metal-oxide nanoparticles combined with visible light irradiation.
- Source :
-
Lasers in surgery and medicine [Lasers Surg Med] 2011 Mar; Vol. 43 (3), pp. 236-40. - Publication Year :
- 2011
-
Abstract
- Background: In recent years nano-metaloxides which easily penetrate into the cells with special interest due to their higher chemical reactivity as compared to that of similar materials in the bulk form. Of particular interest are nano-TiO(2) and ZnO, which have been widely used for their bactericidal and anticancerous properties.<br />Purpose: The aim of the present study was to examine the bactericidal properties of nano-TiO(2) and ZnO combined with visible light on S. aureus and S. epidermitis, known for their high prevalence in infected wounds.<br />Study: Using the technique of electron-spin resonance (ESR) coupled with spin trapping, we examined the ability of TiO(2) and ZnO nanoparticle suspensions in water to produce reactive oxygen species (ROS) with and without visible light irradiation. The possibility of exciting these nanoparticles with visible light in order to enhance their antimicrobial activity was also tested.<br />Results: Electron-spin resonance measurements revealed that ZnO and TiO(2) nanoparticles are able to produce ROS in water suspension. A remarkable enhancement of ROS production was found following illumination with blue light. In addition, illumination significantly enhanced the antibacterial activity of the nanoparticles.<br />Conclusion: The results suggest that nanoparticles combined with visible light can be used for sterilization purposes and may be effective for treating infected wounds.<br /> (Copyright © 2011 Wiley-Liss, Inc.)
- Subjects :
- Anti-Bacterial Agents chemistry
Colony Count, Microbial
Electron Spin Resonance Spectroscopy
Hydroxyl Radical chemical synthesis
Hydroxyl Radical pharmacology
Metal Nanoparticles chemistry
Spin Trapping
Staphylococcus aureus growth & development
Staphylococcus epidermidis growth & development
Superoxides chemical synthesis
Superoxides pharmacology
Titanium chemistry
Zinc Oxide chemistry
Anti-Bacterial Agents pharmacology
Light
Metal Nanoparticles microbiology
Staphylococcus aureus drug effects
Staphylococcus aureus radiation effects
Staphylococcus epidermidis drug effects
Staphylococcus epidermidis radiation effects
Titanium pharmacology
Zinc Oxide pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1096-9101
- Volume :
- 43
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Lasers in surgery and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 21412807
- Full Text :
- https://doi.org/10.1002/lsm.21033