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Plasma pepsinogens, antibodies against Helicobacter pylori, and risk of gastric cancer in the Shanghai Women's Health Study Cohort.
- Source :
-
British journal of cancer [Br J Cancer] 2011 Apr 26; Vol. 104 (9), pp. 1511-6. Date of Electronic Publication: 2011 Mar 15. - Publication Year :
- 2011
-
Abstract
- Background: Circulating pepsinogens can indicate atrophic gastritis, a precursor of gastric cancer. We tested the association between gastric cancer and plasma pepsinogens and antibodies against Helicobacter pylori in a case-control study nested in a prospective cohort.<br />Methods: We selected 141 gastric cancer cases and 282 incidence-density sampled controls. Plasma concentrations of pepsinogens 1 and 2 were measured using ELISA kits, and anti-H. pylori antibodies were measured using a kit specific to Chinese strains. Associations were estimated using conditional logistic regression models adjusted for potential confounders.<br />Results: Gastric cancer subjects were more likely to be anti-H. pylori positive than controls, 97 vs 92%. A plasma pepsinogen 1 (PG1) concentration <50 ng ml(-1) (15% of cases) was associated with a significantly increased risk of gastric cancer (OR 4.23; (95% CI: 1.86-9.63), whereas a plasma pepsinogen 2 (PG2) concentration >6.6 ng ml(-1) (75% of cases) was also associated with a significantly increased risk of gastric cancer (OR 3.62; (95% CI: 1.85-7.09). We also found that the PG1 : 2 ratio had a nearly linear association with gastric cancer risk.<br />Conclusion: Lower plasma PG1 : 2 ratios are associated with a higher risk of gastric cancer. Furthermore, it appears that circulating pepsinogens 1 and 2 may be independently associated with the risk of gastric cancer.
- Subjects :
- Adult
Aged
Biomarkers, Tumor blood
Case-Control Studies
China epidemiology
Cohort Studies
Confounding Factors, Epidemiologic
Female
Helicobacter Infections microbiology
Humans
Linear Models
Middle Aged
Pepsinogen A blood
Pepsinogen C blood
Stomach Neoplasms epidemiology
Women's Health
Antibodies, Bacterial blood
Asian People statistics & numerical data
Helicobacter Infections complications
Helicobacter pylori immunology
Pepsinogens blood
Stomach Neoplasms enzymology
Stomach Neoplasms microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1532-1827
- Volume :
- 104
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- British journal of cancer
- Publication Type :
- Academic Journal
- Accession number :
- 21407214
- Full Text :
- https://doi.org/10.1038/bjc.2011.77