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Tetracycline administration prevents diabetes-induced osteopenia in the rat: initial observations.
- Source :
-
Research communications in chemical pathology and pharmacology [Res Commun Chem Pathol Pharmacol] 1990 Apr; Vol. 68 (1), pp. 27-40. - Publication Year :
- 1990
-
Abstract
- A tetracycline (doxycycline) was administered daily by oral intubation to adult diabetic rats to assess the effect on skeletal tissue; the rationale--osteopenia is a complication of diabetes and tetracyclines (TCs) were recently found to inhibit pathologic collagen loss (e.g. in diabetic rat skin) by a mechanism independent of their antimicrobial efficacy. Osteopenia was induced by streptozotocin-diabetes as indicated by physical (e.g. specific gravity), chemical (e.g. calcium (Ca) content) and ultrastructural characteristics of the femurs, and TC administration (including treatment with a chemically-modified non-antimicrobial analog) appeared to prevent the development of the bone deficiency disease without affecting the severity of hyperglycemia.
- Subjects :
- Administration, Oral
Animals
Bone Diseases, Metabolic etiology
Bone Diseases, Metabolic pathology
Diabetes Mellitus, Experimental chemically induced
Doxycycline administration & dosage
Doxycycline pharmacology
Femur ultrastructure
Hyperglycemia complications
Male
Microscopy, Electron
Rats
Rats, Inbred Strains
Streptozocin
Tetracycline administration & dosage
Bone Diseases, Metabolic prevention & control
Diabetes Mellitus, Experimental complications
Tetracycline pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0034-5164
- Volume :
- 68
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Research communications in chemical pathology and pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 2140619