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Blockade of the antinociception induced by diclofenac, but not of indomethacin, by sulfonylureas and biguanides.
- Source :
-
Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2011 Jul; Vol. 99 (1), pp. 1-6. Date of Electronic Publication: 2011 Mar 17. - Publication Year :
- 2011
-
Abstract
- There is evidence that administration of sulfonylureas, such as glibenclamide and tolbutamide, blocks diclofenac-induced antinociception, suggesting that diclofenac activates ATP-sensitive K(+) channels. However, there is no evidence for the interaction between diclofenac and other hypoglycemic drugs, such as the biguanides metformin or phenformin. Therefore, this work was undertaken to determine whether two sulfonylureas, glibenclamide and glipizide, as well as two biguanides, metformin and phenformin, have any effect on the systemic antinociception that is induced by diclofenac and indomethacin using the rat formalin test as an animal model. Systemic injections of diclofenac (10 to 30mg/kg) and indomethacin (10 to 30mg/kg) produced dose-dependent antinociception during the second phase of the test. Systemic pretreatment with glibenclamide (3 and 10mg/kg), glipizide (3 and 10mg/kg), metformin (100 and 180mg/kg) or phenformin (100 and 180mg/kg) blocked diclofenac-induced systemic antinociception in the second phase of the test (P<0.05). In contrast, pretreatment with glibenclamide, glipizide, metformin or phenformin did not block indomethacin-induced systemic antinociception (P>0.05). These data suggest that diclofenac, but not indomethacin, activated K(+) channels and metformin and phenformin-dependent mechanisms, which resulted in systemic antinociceptive effects in the rat formalin test.<br /> (Copyright © 2011 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Biguanides metabolism
Diclofenac antagonists & inhibitors
Diclofenac metabolism
Drug Interactions physiology
Drug Therapy, Combination
Indomethacin metabolism
Male
Pain Measurement methods
Psychomotor Performance drug effects
Psychomotor Performance physiology
Rats
Rats, Wistar
Sulfonylurea Compounds metabolism
Biguanides administration & dosage
Diclofenac administration & dosage
Indomethacin administration & dosage
Pain Measurement drug effects
Sulfonylurea Compounds administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1873-5177
- Volume :
- 99
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Pharmacology, biochemistry, and behavior
- Publication Type :
- Academic Journal
- Accession number :
- 21397627
- Full Text :
- https://doi.org/10.1016/j.pbb.2011.03.008