Molecular epidemiology of KPC-2- producing Klebsiella pneumoniae isolates in Brazil: the predominance of sequence type 437.

Authors :: Seki LM
Pereira PS
de Souza Mda P
Conceição Mde S
Marques EA
Porto CO
Colnago EM
Alves Cde F
Gomes D
Assef AP
Samuelsen Ø
Asensi MD
Source :: Diagnostic microbiology and infectious disease [Diagn Microbiol Infect Dis] 2011 Jun; Vol. 70 (2), pp. 274-7. Date of Electronic Publication: 2011 Mar 11.
Publication Year :: 2011
Abstract: The aim of this study was to investigate the genetic relatedness of 57 KPC-2-producing Klebsiella pneumoniae isolates from 5 states in Brazil, during 2006-2009. Pulse-field gel electrophoresis analysis identified 10 pulsotypes. The pulsotype designated as Kp-RJ (Klebsiella pneumoniae-Rio de Janeiro) was the dominant clone found in the states of Rio de Janeiro and Espírito Santo. Multilocus sequence typing of Kp-RJ assigned it to ST 437. Sequence types ST11, ST16, ST25, ST70, ST101, ST105, ST423, ST442, and ST443 were also identified. These results indicate the dissemination of a successful KPC-producing clone (ST437) in Brazil, which is a single locus variant of ST258.<br /> (Copyright © 2011 Elsevier Inc. All rights reserved.)

Subjects :: Brazil epidemiology
Electrophoresis, Gel, Pulsed-Field
Genotype
Humans
Klebsiella Infections microbiology
Klebsiella pneumoniae genetics
Klebsiella pneumoniae isolation & purification
Molecular Epidemiology
Multilocus Sequence Typing
Klebsiella Infections epidemiology
Klebsiella pneumoniae classification
Klebsiella pneumoniae enzymology
Molecular Typing
beta-Lactamases biosynthesis

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