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Historical perspectives and the future of adverse reactions associated with haemopoietic stem cells cryopreserved with dimethyl sulfoxide.

Authors :
Cox MA
Kastrup J
Hrubiško M
Source :
Cell and tissue banking [Cell Tissue Bank] 2012 Jun; Vol. 13 (2), pp. 203-15. Date of Electronic Publication: 2011 Mar 11.
Publication Year :
2012

Abstract

A retrospective review of the published literature identified several hundred adverse reactions (e.g. nausea, chills, cardiac arrhythmias, neurological symptoms and respiratory arrest) associated with the transplantation of stem cells cryopreserved with dimethyl sulfoxide. The occurrences of these are generally accepted as commonplace, as the majority of reactions are transient, whilst a few patients may require clinical treatment. This exploratory study is a collation of the historical data and the expectations for the notification of serious adverse reactions. Outline information is presented on the development of related European Directives, some technical aspects of dimethyl sulfoxide and the sequential stages of preservation and administration.

Details

Language :
English
ISSN :
1573-6814
Volume :
13
Issue :
2
Database :
MEDLINE
Journal :
Cell and tissue banking
Publication Type :
Academic Journal
Accession number :
21394484
Full Text :
https://doi.org/10.1007/s10561-011-9248-2