Back to Search
Start Over
Historical perspectives and the future of adverse reactions associated with haemopoietic stem cells cryopreserved with dimethyl sulfoxide.
- Source :
-
Cell and tissue banking [Cell Tissue Bank] 2012 Jun; Vol. 13 (2), pp. 203-15. Date of Electronic Publication: 2011 Mar 11. - Publication Year :
- 2012
-
Abstract
- A retrospective review of the published literature identified several hundred adverse reactions (e.g. nausea, chills, cardiac arrhythmias, neurological symptoms and respiratory arrest) associated with the transplantation of stem cells cryopreserved with dimethyl sulfoxide. The occurrences of these are generally accepted as commonplace, as the majority of reactions are transient, whilst a few patients may require clinical treatment. This exploratory study is a collation of the historical data and the expectations for the notification of serious adverse reactions. Outline information is presented on the development of related European Directives, some technical aspects of dimethyl sulfoxide and the sequential stages of preservation and administration.
- Subjects :
- Europe
Hematopoietic Stem Cell Transplantation instrumentation
Hematopoietic Stem Cell Transplantation legislation & jurisprudence
History, 20th Century
Humans
Cryopreservation methods
Cryoprotective Agents adverse effects
Dimethyl Sulfoxide adverse effects
Hematopoietic Stem Cell Transplantation adverse effects
Hematopoietic Stem Cell Transplantation history
Hematopoietic Stem Cells cytology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-6814
- Volume :
- 13
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cell and tissue banking
- Publication Type :
- Academic Journal
- Accession number :
- 21394484
- Full Text :
- https://doi.org/10.1007/s10561-011-9248-2