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An elastase-dependent attenuated heterologous swine influenza virus protects against pandemic H1N1 2009 influenza challenge in swine.
- Source :
-
Vaccine [Vaccine] 2011 Apr 12; Vol. 29 (17), pp. 3118-23. Date of Electronic Publication: 2011 Mar 05. - Publication Year :
- 2011
-
Abstract
- Influenza virus infections continue to cause production losses in the agricultural industry in addition to being a human public health concern. The primary method to control influenza is through vaccination. However, currently used killed influenza virus vaccines must be closely matched to the challenge virus. The ability of an elastase-dependent live attenuated influenza A virus was evaluated to protect pigs against the pandemic H1N1 2009 influenza virus. Pigs vaccinated intranasally or intratracheally with the elastase-dependent swine influenza virus (SIV) vaccine had significantly reduced macroscopic and microscopic lung lesions and lower viral loads in the lung and in nasal swabs. Thus, elastase-dependent SIV mutants can be used as live-virus vaccines against swine influenza in pigs. In addition, low levels of cross-neutralizing antibodies to H1N1 2009 were elicited prior to challenge by the swine adapted H1N1 avian strain vaccine.<br /> (Crown Copyright © 2011. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Administration, Inhalation
Administration, Intranasal
Animals
Antibodies, Neutralizing blood
Antibodies, Viral blood
Cross Protection
Cross Reactions
Humans
Influenza A virus genetics
Influenza Vaccines administration & dosage
Lung pathology
Lung virology
Nasal Cavity virology
Orthomyxoviridae Infections immunology
Swine
Swine Diseases immunology
Viral Load
Influenza A virus immunology
Influenza Vaccines immunology
Orthomyxoviridae Infections prevention & control
Swine Diseases prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2518
- Volume :
- 29
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 21382482
- Full Text :
- https://doi.org/10.1016/j.vaccine.2011.02.069