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Decreased fertility among female childhood cancer survivors who received 22-27 Gy hypothalamic/pituitary irradiation: a report from the Childhood Cancer Survivor Study.
- Source :
-
Fertility and sterility [Fertil Steril] 2011 May; Vol. 95 (6), pp. 1922-7, 1927.e1. Date of Electronic Publication: 2011 Mar 03. - Publication Year :
- 2011
-
Abstract
- Objective: To evaluate the effect of hypothalamic/pituitary radiation (HPT RT) dose on the occurrence of first pregnancy.<br />Design: Retrospective cohort study of childhood cancer 5-year survivors (CCS) diagnosed between 1970 and 1986 before 21 years of age at one of 26 North American pediatric cancer treatment centers.<br />Setting: Self-administered questionnaire.<br />Patient(s): A total of 3,619 female CCS who participated in the Childhood Cancer Survivor Study and received no or scatter (≤0.1 Gy) radiation to the ovaries and 2,081 female siblings (Sibs) of the participants.<br />Intervention(s): None.<br />Main Outcome Measure(s): Self-reported pregnancy events.<br />Result(s): As a group, CCS were as likely to report being pregnant as Sibs (hazard ratio 1.07, 95% confidence interval 0.97-1.19). Multivariable models showed a significant decrease in the risk of pregnancy with HPT RT doses≥22 Gy compared with those CCS receiving no HPT RT.<br />Conclusion(s): These results support the hypothesis that exposures of 22-27 Gy HPT RT may be a contributing factor to infertility among female CCS.<br /> (Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Age of Onset
Child
Cohort Studies
Female
Humans
Hypothalamus pathology
Infertility, Female epidemiology
Neoplasms epidemiology
Neoplasms pathology
Neoplasms rehabilitation
Pituitary Gland pathology
Pregnancy
Radiation Injuries epidemiology
Radiotherapy Dosage
Retrospective Studies
Hypothalamus radiation effects
Infertility, Female etiology
Neoplasms radiotherapy
Pituitary Gland radiation effects
Survivors
Subjects
Details
- Language :
- English
- ISSN :
- 1556-5653
- Volume :
- 95
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Fertility and sterility
- Publication Type :
- Academic Journal
- Accession number :
- 21376314
- Full Text :
- https://doi.org/10.1016/j.fertnstert.2011.02.002