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Bone resorption in orthotopic and heterotopic bone of dichloromethylene bisphosphonate-treated rats.
- Source :
-
Journal of orthopaedic research : official publication of the Orthopaedic Research Society [J Orthop Res] 1990 Mar; Vol. 8 (2), pp. 213-9. - Publication Year :
- 1990
-
Abstract
- The effect of the bisphosphonate dichloromethylene bisphosphonate (Cl2MBP) on orthotopic and heterotopic bone, induced by implants of demineralized bone matrix (DBM) in rats, was analyzed, with special reference to bone resorption. The heterotopic bone was formed by induction for 3 weeks; at this time, the rats were given daily subcutaneous injections of 3 mg/kg of body weight of Cl2MBP or saline, until sacrifice. Prior to the start of treatment, the animals were given 45Ca and [3H]proline to label the inorganic and organic components of bone, respectively. Groups of rats were sacrificed at intervals from 1 to 31 days after isotope injection, and the net formation of bone and the elimination rates of the two isotopes were studied in the heterotopic bone, in diaphyseal and metaphyseal bone, and in teeth. The treatment with Cl2MBP caused a doubling of the daily net increase in mineral of the induced heterotopic bone, and a less pronounced increase in the ash content of tibiae. The treatment decreased the elimination rates of both isotopes in the orthotopic and heterotopic bone, showing that decreased bone resorption is the cause of the increased net bone formation.
- Subjects :
- Animals
Bone Density
Bone Resorption metabolism
Bone and Bones metabolism
Bone and Bones physiopathology
Calcium metabolism
Choristoma drug therapy
Male
Proline metabolism
Rats
Rats, Inbred Strains
Bone Resorption physiopathology
Bone and Bones drug effects
Clodronic Acid pharmacology
Diphosphonates pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0736-0266
- Volume :
- 8
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of orthopaedic research : official publication of the Orthopaedic Research Society
- Publication Type :
- Academic Journal
- Accession number :
- 2137534
- Full Text :
- https://doi.org/10.1002/jor.1100080209