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Comparative evaluation of GFAAS and ICP-MS for analyses of cadmium in blood.
- Source :
-
Industrial health [Ind Health] 2011; Vol. 49 (3), pp. 338-43. Date of Electronic Publication: 2011 Mar 01. - Publication Year :
- 2011
-
Abstract
- Cadmium in blood (Cd-B) is an important indicator, next to Cd in urine, in biological monitoring of exposure to Cd. The present study was initiated to examine compatibility in results of analysis for Cd-B between graphite furnace atomic absorption spectrophotometry (GFAAS) and inductively-coupled plasma mass-spectrometry (ICP-MS). For this purpose, 1,159 blood samples were collected from adult women (with no occupational exposure to Cd) in eight prefectures nation-widely in Japan. The samples were analyzed by the two methods; geometric mean (the maximum) concentrations were 1.22 (6.90) μg/l by ICP-MS, and 1.47 (7.40) μg/l by GFAAS. Statistical analyses showed that there was a close correlation between the results by the two methods. The regression line (with ICP-MS and GFAAS results as an independent variable and a dependent variable, respectively) had a slope close to one and an intercept next to zero to suggest that ICP-MS gave values compatible with that of GFAAS. Further analysis with the ratio of Cd-B by GFAAS over that by ICP-MS revealed that the two results were close to each other, and that the agreement was even closer when Cd-B was >2 μg/l. Thus, the two methods can be employed inter-convertibly when Cd-B is relatively high, e.g. >2 μg/l. Care may need to be practiced, however, for possible 'between methods' difference when Cd-B is low, e.g., ≤2 μg/l.
- Subjects :
- Adult
Aged
Clinical Chemistry Tests
Confidence Intervals
Female
Graphite
Humans
Japan
Mass Spectrometry instrumentation
Mass Spectrometry methods
Middle Aged
Reference Values
Regression Analysis
Reproducibility of Results
Spectrophotometry, Atomic methods
Statistics as Topic
Women's Health
Young Adult
Cadmium blood
Occupational Exposure adverse effects
Spectrophotometry, Atomic instrumentation
Subjects
Details
- Language :
- English
- ISSN :
- 1880-8026
- Volume :
- 49
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Industrial health
- Publication Type :
- Academic Journal
- Accession number :
- 21372439
- Full Text :
- https://doi.org/10.2486/indhealth.ms1194