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Class II MHC antigen-positive macrophages from human placentae suppress strong MLR and CML reactions.
Class II MHC antigen-positive macrophages from human placentae suppress strong MLR and CML reactions.
- Source :
-
Cellular immunology [Cell Immunol] 1990 Jan; Vol. 125 (1), pp. 235-46. - Publication Year :
- 1990
-
Abstract
- Placental adherent cells (PAC), derived by mild enzymic digestion of human placentae and adherence to plastic, were tested for their ability to suppress MLR and CML reactions. Stimulation of allogeneic T cells by cord blood mononuclear cells or by a strongly stimulatory B lymphoblastoid cell line were consistently inhibited by all PAC preparations tested. PAC were fractionated by Fc rosetting and Percoll gradients to produce a number of bands. Suppression correlated with the content of macrophages in each band and was strongest in band 5 which generally contained 94-100% macrophages. The suppressive effect was not inhibited by indomethacin. The possible role of macrophages in suppressing immune reactivity in the placenta is discussed.
Details
- Language :
- English
- ISSN :
- 0008-8749
- Volume :
- 125
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cellular immunology
- Publication Type :
- Academic Journal
- Accession number :
- 2136719
- Full Text :
- https://doi.org/10.1016/0008-8749(90)90077-5