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Class II MHC antigen-positive macrophages from human placentae suppress strong MLR and CML reactions.

Class II MHC antigen-positive macrophages from human placentae suppress strong MLR and CML reactions.

Authors :
Uren SJ
Boyle W
Source :
Cellular immunology [Cell Immunol] 1990 Jan; Vol. 125 (1), pp. 235-46.
Publication Year :
1990

Abstract

Placental adherent cells (PAC), derived by mild enzymic digestion of human placentae and adherence to plastic, were tested for their ability to suppress MLR and CML reactions. Stimulation of allogeneic T cells by cord blood mononuclear cells or by a strongly stimulatory B lymphoblastoid cell line were consistently inhibited by all PAC preparations tested. PAC were fractionated by Fc rosetting and Percoll gradients to produce a number of bands. Suppression correlated with the content of macrophages in each band and was strongest in band 5 which generally contained 94-100% macrophages. The suppressive effect was not inhibited by indomethacin. The possible role of macrophages in suppressing immune reactivity in the placenta is discussed.

Details

Language :
English
ISSN :
0008-8749
Volume :
125
Issue :
1
Database :
MEDLINE
Journal :
Cellular immunology
Publication Type :
Academic Journal
Accession number :
2136719
Full Text :
https://doi.org/10.1016/0008-8749(90)90077-5