Back to Search
Start Over
Tec family kinases: regulation of FcεRI-mediated mast-cell activation.
- Source :
-
The FEBS journal [FEBS J] 2011 Jun; Vol. 278 (12), pp. 1990-2000. Date of Electronic Publication: 2011 Mar 29. - Publication Year :
- 2011
-
Abstract
- Mast cells express the high-affinity receptor for IgE (FcεRI) and are key players in type I hypersensitivity reactions. They are critically involved in the development of allergic rhinitis, allergic asthma and systemic anaphylaxis, however, they also regulate normal physiological processes that link innate and adaptive immune responses. Thus, their activation has to be tightly controlled. One group of signaling molecules that are activated upon FcεRI stimulation is formed by Tec family kinases, and three members of this kinase family (Btk, Itk and Tec) are expressed in mast cells. Many studies have revealed important functions of Tec kinases in signaling pathways downstream of the antigen receptors in lymphocytes. This review summarizes the current knowledge about the function of Tec family kinases in FcεRI-mediated signaling pathways in mast cell.<br /> (© 2011 The Authors Journal compilation © 2011 FEBS.)
- Subjects :
- Agammaglobulinaemia Tyrosine Kinase
Animals
Cytokines biosynthesis
Humans
Hypersensitivity, Immediate enzymology
Hypersensitivity, Immediate immunology
Mice
Models, Immunological
Signal Transduction immunology
Mast Cells enzymology
Mast Cells immunology
Protein-Tyrosine Kinases immunology
Receptors, IgE metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1742-4658
- Volume :
- 278
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- The FEBS journal
- Publication Type :
- Academic Journal
- Accession number :
- 21362140
- Full Text :
- https://doi.org/10.1111/j.1742-4658.2011.08073.x