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Toll-like receptors 7 and 8 expression is associated with poor outcome and greater inflammatory response in acute ischemic stroke.
- Source :
-
Clinical immunology (Orlando, Fla.) [Clin Immunol] 2011 May; Vol. 139 (2), pp. 193-8. Date of Electronic Publication: 2011 Feb 26. - Publication Year :
- 2011
-
Abstract
- Toll-like receptors are innate immunity receptors that activate inflammation and adaptive immunity. Our objectives were to analyze the association between TLR3, 7, 8 and 9 expressions and clinical outcome in patients with ischemic stroke and the expression of inflammatory molecules. One hundred-ten patients with ischemic stroke were included within 12h of symptoms onset. Stroke severity was evaluated by the NIHSS, and functional outcome was assessed at 3 months by the modified Rankin Scale. Infarct volume at 4-7 days was measured on Computed Tomography imaging. TLR7 and TLR8 at different time points were independently associated with poor outcome. TLR8 was also correlated with infarct volumes. Furthermore, TLR7 and TLR8 on admission were correlated with levels of IL6 and IL1β at 24h, 72 h and 7 days. In conclusion, TLR 7 and TLR8 expressions are associated with poor outcome and greater inflammatory response in acute ischemic stroke.<br /> (Copyright © 2011 Elsevier Inc. All rights reserved.)
- Subjects :
- Aged
Aged, 80 and over
Atrial Fibrillation physiopathology
Blood Glucose metabolism
Brain Infarction etiology
Brain Infarction pathology
C-Reactive Protein metabolism
Cell Adhesion Molecules blood
Female
Gene Expression genetics
Gene Expression immunology
Humans
Inflammation blood
Interleukin-1beta blood
Interleukin-6 blood
Leukocytes, Mononuclear metabolism
Male
Matrix Metalloproteinase 9 blood
Middle Aged
Prognosis
Stroke etiology
Stroke pathology
Stroke physiopathology
Toll-Like Receptor 3 genetics
Toll-Like Receptor 3 metabolism
Toll-Like Receptor 7 genetics
Toll-Like Receptor 8 genetics
Toll-Like Receptor 9 genetics
Toll-Like Receptor 9 metabolism
Tumor Necrosis Factor-alpha blood
Brain Ischemia complications
Stroke diagnosis
Stroke metabolism
Toll-Like Receptor 7 metabolism
Toll-Like Receptor 8 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1521-7035
- Volume :
- 139
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Clinical immunology (Orlando, Fla.)
- Publication Type :
- Academic Journal
- Accession number :
- 21354862
- Full Text :
- https://doi.org/10.1016/j.clim.2011.02.001