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[Pharmacodynamic experiment of the antivirus effect of Houttuynia cordata injection on influenza virus in mice].
- Source :
-
Yao xue xue bao = Acta pharmaceutica Sinica [Yao Xue Xue Bao] 2010 Mar; Vol. 45 (3), pp. 399-402. - Publication Year :
- 2010
-
Abstract
- It is to investigate the effect of two kinds of Houttuynia Cordata Injection on preventing and treating H1N1 influenza virus infection in mice. Pneumonia model was set up by intranasal infection of the normal and immunocompromised mice with influenza virus FM1 and PR8. The two injections were administered before and after the administration of virus, separately, and the lung index was observed. The results showed that the two preparations have obvious therapeutic effect on normal mice infected with influenza virus FM1 and PR8. And to FM1, the new injection's effect is better at small dosage. The results also showed that the two preparations have obvious prophylactic effect on immunodepressed mice infected with influenza virus FM1 and PR8. And to PR8, the old injection's effect is better at small dosage. Houttuynia Cordata Injection can improve the mice pneumonia caused by influenza virus H1N1 and decrease the lung index markedly. It has a remarkable preventive and therapeutic effect on H1N1 influenza virus in mice.
- Subjects :
- Animals
Antiviral Agents administration & dosage
Antiviral Agents therapeutic use
Drugs, Chinese Herbal administration & dosage
Drugs, Chinese Herbal isolation & purification
Female
Influenza A Virus, H1N1 Subtype immunology
Injections
Male
Mice
Mice, Inbred ICR
Orthomyxoviridae Infections complications
Orthomyxoviridae Infections immunology
Orthomyxoviridae Infections prevention & control
Plants, Medicinal chemistry
Pneumonia, Viral etiology
Pneumonia, Viral prevention & control
Random Allocation
Drugs, Chinese Herbal therapeutic use
Houttuynia chemistry
Immunocompromised Host
Influenza A Virus, H1N1 Subtype drug effects
Orthomyxoviridae Infections drug therapy
Pneumonia, Viral drug therapy
Subjects
Details
- Language :
- Chinese
- ISSN :
- 0513-4870
- Volume :
- 45
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Yao xue xue bao = Acta pharmaceutica Sinica
- Publication Type :
- Academic Journal
- Accession number :
- 21351520