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[Synthesis and antidepressant activities of aryl alkanol piperidine derivatives].
- Source :
-
Yao xue xue bao = Acta pharmaceutica Sinica [Yao Xue Xue Bao] 2010 Mar; Vol. 45 (3), pp. 324-9. - Publication Year :
- 2010
-
Abstract
- To explore novel monoamine reuptake inhibitor with antidepressant activity, a series of substituted aryl alkanol piperidine derivatives were designed and synthesized. All of them were new compounds, and their structures were confirmed with 1H NMR and HR-MS. The results showed that compounds 4, 5 and 8 displayed strong 5-HT, NA and DA reuptake inhibiting activities in vitro. Among the tested compounds, 4, 5 and 13 exhibited potent antidepressant activities in the mice forced swimming test. Compounds 4 and 5 have potent antidepressant activities and are worth further development.
- Subjects :
- Animals
Antidepressive Agents chemistry
Dopamine metabolism
Male
Mice
Molecular Structure
Motor Activity drug effects
Neurotransmitter Uptake Inhibitors chemical synthesis
Neurotransmitter Uptake Inhibitors chemistry
Neurotransmitter Uptake Inhibitors pharmacology
Norepinephrine metabolism
Piperidines chemistry
Random Allocation
Rats
Rats, Sprague-Dawley
Serotonin metabolism
Structure-Activity Relationship
Swimming
Synaptosomes metabolism
Antidepressive Agents chemical synthesis
Antidepressive Agents pharmacology
Piperidines chemical synthesis
Piperidines pharmacology
Subjects
Details
- Language :
- Chinese
- ISSN :
- 0513-4870
- Volume :
- 45
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Yao xue xue bao = Acta pharmaceutica Sinica
- Publication Type :
- Academic Journal
- Accession number :
- 21351508