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TNF-α downregulates filaggrin and loricrin through c-Jun N-terminal kinase: role for TNF-α antagonists to improve skin barrier.
- Source :
-
The Journal of investigative dermatology [J Invest Dermatol] 2011 Jun; Vol. 131 (6), pp. 1272-9. Date of Electronic Publication: 2011 Feb 24. - Publication Year :
- 2011
-
Abstract
- Filaggrin (FLG), loricrin (LOR), and involucrin are important epidermal barrier proteins. As psoriasis is characterized by overexpression of tumor necrosis factor-α (TNF-α) and impaired skin barrier, we investigated the expression of skin barrier proteins in psoriasis patients and whether their expression was modulated by TNF-α. The expression of FLG and LOR was found to be decreased in lesional and non-lesional skin of psoriasis patients. A correlation was found between the expression of TNF-α and epidermal barrier proteins in psoriasis. TNF-α was found to modulate the expression of FLG and LOR via a c-Jun N-terminal kinase-dependent pathway. Importantly, we report that clinical treatment of psoriasis patients with a TNF-α antagonist results in significant enhancement of epidermal barrier protein expression. Our current study suggests that TNF inhibits barrier protein expression, and TNF-α antagonists may contribute to clinical improvement in patients with psoriasis by improving barrier protein expression.
- Subjects :
- Adult
Down-Regulation
Filaggrin Proteins
Humans
Intermediate Filament Proteins analysis
Intermediate Filament Proteins genetics
Membrane Proteins analysis
Membrane Proteins genetics
Psoriasis metabolism
Tumor Necrosis Factor-alpha antagonists & inhibitors
Intermediate Filament Proteins antagonists & inhibitors
JNK Mitogen-Activated Protein Kinases physiology
Membrane Proteins antagonists & inhibitors
Psoriasis drug therapy
Skin metabolism
Tumor Necrosis Factor-alpha physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1523-1747
- Volume :
- 131
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The Journal of investigative dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 21346775
- Full Text :
- https://doi.org/10.1038/jid.2011.24