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TNF-α downregulates filaggrin and loricrin through c-Jun N-terminal kinase: role for TNF-α antagonists to improve skin barrier.

Authors :
Kim BE
Howell MD
Guttman-Yassky E
Gilleaudeau PM
Cardinale IR
Boguniewicz M
Krueger JG
Leung DY
Source :
The Journal of investigative dermatology [J Invest Dermatol] 2011 Jun; Vol. 131 (6), pp. 1272-9. Date of Electronic Publication: 2011 Feb 24.
Publication Year :
2011

Abstract

Filaggrin (FLG), loricrin (LOR), and involucrin are important epidermal barrier proteins. As psoriasis is characterized by overexpression of tumor necrosis factor-α (TNF-α) and impaired skin barrier, we investigated the expression of skin barrier proteins in psoriasis patients and whether their expression was modulated by TNF-α. The expression of FLG and LOR was found to be decreased in lesional and non-lesional skin of psoriasis patients. A correlation was found between the expression of TNF-α and epidermal barrier proteins in psoriasis. TNF-α was found to modulate the expression of FLG and LOR via a c-Jun N-terminal kinase-dependent pathway. Importantly, we report that clinical treatment of psoriasis patients with a TNF-α antagonist results in significant enhancement of epidermal barrier protein expression. Our current study suggests that TNF inhibits barrier protein expression, and TNF-α antagonists may contribute to clinical improvement in patients with psoriasis by improving barrier protein expression.

Details

Language :
English
ISSN :
1523-1747
Volume :
131
Issue :
6
Database :
MEDLINE
Journal :
The Journal of investigative dermatology
Publication Type :
Academic Journal
Accession number :
21346775
Full Text :
https://doi.org/10.1038/jid.2011.24