Back to Search
Start Over
The effectiveness of a biologic agent on axial manifestations of psoriatic arthritis. A twelve months observational study in a group of patients treated with etanercept.
- Source :
-
Clinical and experimental rheumatology [Clin Exp Rheumatol] 2011 Jan-Feb; Vol. 29 (1), pp. 80-4. Date of Electronic Publication: 2011 Feb 23. - Publication Year :
- 2011
-
Abstract
- Objectives: To investigate the effectiveness of etanercept on axial manifestations of a group of patients with established psoriatic arthritis (PsA).<br />Methods: This was a multicentre observational study. PsA was classified based on the CASPAR criteria. Inclusion criteria were refractory PsA with axial manifestations and suitability for anti TNF-α therapy. Effectiveness was defined according to the ASAS response criteria (BASDAI: 50% relative or absolute change of 20mm and expert opinion in favour of continuation), and on the improvements of BASFI, anthropometric measures, PASI, ESR and CRP at 12 months. PASI 50 and 75 were also assessed, as well as the ACR20 and ACR50 response criteria for patients with peripheral arthritis. Comparisons between baseline and after 12-month treatment were done using the Wilcoxon signed rank test for the end-points considered.<br />Results: The study included 32 patients (25/7 M/F; median age 51yrs; 25th-75th percentiles: 34.5-58.7; median disease duration 14.5 yrs; 25th-75th percentiles: 9.2-17.00). Effectiveness of etanercept was observed in 72% of patients for the BASDAI (p<0.001), in 68% for the BASFI (p<0.001), in 76% for ESR (p<0.001) and in 68% of patients for CRP (p<0.01). The PASI improved in 72% of patients treated (p<0.0001), while PASI 50 and PASI 75 was reached in 81% and 55% of patients, respectively. ACR 20 and 50 was reached in 78 and 56% of patients with peripheral involvement respectively.<br />Conclusions: The present study has shown that etanercept is effective on axial manifestations of established PsA, confirming the positive effects of anti TNF-α therapy on clinical manifestations of the disease.
- Subjects :
- Adult
Aged
Arthritis, Psoriatic complications
Arthritis, Psoriatic physiopathology
Etanercept
Female
Health Status
Humans
Male
Middle Aged
Pain, Intractable drug therapy
Pain, Intractable etiology
Pain, Intractable physiopathology
Range of Motion, Articular
Remission Induction
Severity of Illness Index
Skin drug effects
Skin pathology
Spine drug effects
Spine pathology
Spine physiopathology
Spondylitis etiology
Spondylitis physiopathology
Treatment Failure
Treatment Outcome
Antirheumatic Agents therapeutic use
Arthritis, Psoriatic drug therapy
Immunoglobulin G therapeutic use
Receptors, Tumor Necrosis Factor therapeutic use
Spondylitis drug therapy
Tumor Necrosis Factor-alpha antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 0392-856X
- Volume :
- 29
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Clinical and experimental rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 21345296