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A role for orexin in central vestibular motor control.
- Source :
-
Neuron [Neuron] 2011 Feb 24; Vol. 69 (4), pp. 793-804. - Publication Year :
- 2011
-
Abstract
- The absence of orexin results in narcolepsy-cataplexy. While the function of the central orexinergic system in sleep regulation has been well studied, the role of orexin in motor control is largely unknown. Here, we show that orexin-A acts via OX(1) and OX(2) receptors to directly depolarize neurons in the rat lateral vestibular nucleus (LVN), a subcortical motor center, and enhance their sensitivity. A dual ionic mechanism involving both Na+-Ca²+ exchangers and inward rectifier K+ channels underlies these effects. Furthermore, orexin-A regulates central vestibular-mediated posture, motor balance and negative geotaxis. Orexin is critical when an animal is facing a major motor challenge as opposed to during rest and general movements. Therefore, orexin participates not only in sleep and emotion (nonsomatic) but also in motor (somatic) regulation, suggesting that the central orexinergic system plays an important role in somatic-nonsomatic integration. These findings may account for why the absence of orexin results in narcolepsy-cataplexy.<br /> (Copyright © 2011 Elsevier Inc. All rights reserved.)
- Subjects :
- Analysis of Variance
Animals
Animals, Newborn
Behavior, Animal
Benzoxazoles pharmacology
Drug Interactions
Electric Stimulation methods
Exploratory Behavior drug effects
Hindlimb Suspension methods
In Vitro Techniques
Intracellular Signaling Peptides and Proteins pharmacology
Male
Membrane Potentials drug effects
Membrane Potentials physiology
Microinjections methods
Motor Activity drug effects
Motor Activity physiology
Naphthyridines
Neurons drug effects
Neuropeptides pharmacology
Orexins
Patch-Clamp Techniques
Psychomotor Performance drug effects
Rats
Receptors, Neuropeptide agonists
Receptors, Neuropeptide antagonists & inhibitors
Receptors, Neuropeptide genetics
Receptors, Neuropeptide metabolism
Sodium-Calcium Exchanger antagonists & inhibitors
Thiourea analogs & derivatives
Thiourea pharmacology
Urea analogs & derivatives
Urea pharmacology
Intracellular Signaling Peptides and Proteins metabolism
Neurons physiology
Neuropeptides metabolism
Vestibular Nucleus, Lateral cytology
Vestibular Nucleus, Lateral metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1097-4199
- Volume :
- 69
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Neuron
- Publication Type :
- Academic Journal
- Accession number :
- 21338887
- Full Text :
- https://doi.org/10.1016/j.neuron.2011.01.026