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Prevalence of chronic kidney disease and anemia in patients with coronary artery disease with normal serum creatinine undergoing percutaneous coronary interventions: relation to New York Heart Association class.
- Source :
-
The Israel Medical Association journal : IMAJ [Isr Med Assoc J] 2010 Aug; Vol. 12 (8), pp. 489-93. - Publication Year :
- 2010
-
Abstract
- Background: Kidney disease and cardiovascular disease seem to be lethally synergistic and both are approaching the epidemic level. A reduced glomerular filtration rate is associated with increased mortality risk in patients with heart failure. Many patients with congestive heart failure are anemic. Anemia is very often associated with chronic kidney disease.<br />Objectives: To assess--in relation to New York Heart Association class--the prevalence of anemia and chronic kidney disease in patients with normal serum creatinine in a cohort of 526 consecutive patients with coronary artery disease undergoing percutaneous coronary interventions.<br />Methods: GFR was estimated using the simplified MDRD formula, the Cockcroft-Gault formula, the Jeliffe and the novel CKD-EPI formula.<br />Results: According to the WHO definition the prevalence of anemia in our study was 21%. We observed a progressive decline in GFR and hemoglobin concentration together with a rise in NYHA class. Significant correlations were observed between eGFR and systolic blood pressure, diastolic blood pressure, age, NYHA class, complications of PCI, including bleeding, and major adverse cardiac events.<br />Conclusions: The prevalence of anemia and chronic kidney disease is high in patients undergoing PCI despite normal serum creatinine, particularly in higher NYHA class. Lower eGFR and hemoglobin are associated with more complications, including bleeding after PCI and higher prevalence of major adverse cardiac events. In patients with risk factors for cardiovascular disease, GFR should be estimated since renal dysfunction and subsequent anemia are important risk factors for cardiovascular morbidity and mortality.
- Subjects :
- American Heart Association
Anemia blood
Cohort Studies
Comorbidity
Coronary Artery Disease blood
Coronary Artery Disease therapy
Female
Humans
Kidney Failure, Chronic blood
Male
Middle Aged
New York
Poland epidemiology
Prevalence
Prospective Studies
Severity of Illness Index
Sex Distribution
United States
Anemia epidemiology
Angioplasty, Balloon, Coronary
Coronary Artery Disease epidemiology
Creatinine blood
Kidney Failure, Chronic epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1565-1088
- Volume :
- 12
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- The Israel Medical Association journal : IMAJ
- Publication Type :
- Academic Journal
- Accession number :
- 21337818