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Association of genetic variants of the histamine H1 and muscarinic M3 receptors with BMI and HbA1c values in patients on antipsychotic medication.
- Source :
-
Psychopharmacology [Psychopharmacology (Berl)] 2011 Jul; Vol. 216 (2), pp. 257-65. Date of Electronic Publication: 2011 Feb 19. - Publication Year :
- 2011
-
Abstract
- Rationale: Antipsychotic affinity for the histamine H1 receptor and the muscarinic M3 receptor have been associated with the side effects weight gain, and development of diabetes, respectively.<br />Objectives: We investigated polymorphisms of the histamine H1 (HRH1) and muscarinic acetylcholine receptor M3 (CHRM3) receptor genes for an association with body mass index (BMI) and glycated hemoglobin (HbA1c).<br />Methods: We included 430 Caucasian patients with a non-affective psychotic disorder using antipsychotics for at least 3 months. Primary endpoints of the study were cross-sectionally measured BMI and HbA1c; secondary endpoints were obesity and hyperglycaemia. Two single-nucleotide polymorphisms (SNPs) in the HRH1 gene, rs346074 and rs346070, and one SNP in the CHRM3 gene, rs3738435, were genotyped. Our primary hypothesis in this study was an interaction between genotype on BMI and antipsychotic affinity for the H1 and M3 receptor.<br />Results: A significant association of interaction between haplotype rs346074-rs346070 and BMI (p value 0.025) and obesity (p value 0.005) in patients using high-H1 affinity antipsychotics versus patients using low-H1 affinity antipsychotics was found. There was no association of CHRM3 gene variant rs3738435 with BMI, and we observed no association with HbA1c or hyperglycaemia in any of the variants.<br />Conclusions: This study, for the first time, demonstrates a significant association between HRH1 variants and BMI in patients with a psychotic disorder using antipsychotics. In future, genotyping of HRH1 variants may help predicting weight gain in patients using antipsychotics.
- Subjects :
- Adolescent
Adult
Aged
Antipsychotic Agents adverse effects
Antipsychotic Agents metabolism
Body Mass Index
Cross-Sectional Studies
Female
Genetic Variation
Glycated Hemoglobin metabolism
Humans
Hyperglycemia epidemiology
Male
Middle Aged
Obesity epidemiology
Polymorphism, Single Nucleotide
Psychotic Disorders genetics
Receptors, Histamine H1 metabolism
Weight Gain drug effects
Young Adult
Antipsychotic Agents pharmacology
Psychotic Disorders drug therapy
Receptor, Muscarinic M3 genetics
Receptors, Histamine H1 genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1432-2072
- Volume :
- 216
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Psychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 21336576
- Full Text :
- https://doi.org/10.1007/s00213-011-2211-x