Non-linear relationships of cerebrospinal fluid biomarker levels with cognitive function: an observational study.

Authors :: Williams JH
Wilcock GK
Seeburger J
Dallob A
Laterza O
Potter W
Smith AD
Source :: Alzheimer's research & therapy [Alzheimers Res Ther] 2011 Feb 17; Vol. 3 (1), pp. 5. Date of Electronic Publication: 2011 Feb 17.
Publication Year :: 2011
Abstract: Introduction: Levels of cerebrospinal fluid (CSF) β-amyloid (Aβ) and Tau proteins change in Alzheimer's disease (AD). We tested if the relationships of these biomarkers with cognitive impairment are linear or non-linear.<br />Methods: We assessed cognitive function and assayed CSF Aβ and Tau biomarkers in 95 non-demented volunteers and 97 AD patients. We then tested non-linearities in their inter-relations.<br />Results: CSF biomarkers related to cognitive function in the non-demented range of cognition, but these relations were weak or absent in the patient range; Aβ1-40's relationship was biphasic.<br />Conclusions: Major biomarker changes precede clinical AD and index cognitive impairment in AD poorly, if at all.

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