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Polymerase trafficking: A role for transcription factors in preventing replication fork arrest.
- Source :
-
Transcription [Transcription] 2010 Nov; Vol. 1 (3), pp. 136-139. Date of Electronic Publication: 2010 Aug 30. - Publication Year :
- 2010
-
Abstract
- Replication forks and transcription complexes often collide, which can result in mutagenesis and chromosomal rearrangements. Recent studies of E. coli demonstrate a role for transcription factors in reducing conflicts between replication and transcription. These findings suggest that transcription regulators preserve genome integrity by preventing replication fork arrest.
Details
- Language :
- English
- ISSN :
- 2154-1272
- Volume :
- 1
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Transcription
- Publication Type :
- Academic Journal
- Accession number :
- 21326887
- Full Text :
- https://doi.org/10.4161/trns.1.3.13488