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Amino acid substitution in HCV core region and genetic variation near the IL28B gene affect viral dynamics during telaprevir, peginterferon and ribavirin treatment.
- Source :
-
Intervirology [Intervirology] 2012; Vol. 55 (6), pp. 417-25. Date of Electronic Publication: 2012 Jun 08. - Publication Year :
- 2012
-
Abstract
- Objectives: Genetic variation near the IL28B gene and substitution of aa 70 and 91 in the core region of HCV-1b are useful as predictors of treatment efficacy to telaprevir/pegylated interferon (PEG-IFN)/ribavirin, but its impact on viral dynamics is not clear.<br />Methods: This study investigated predictive factors of viral dynamics during 12- or 24-week regimen of triple therapy in 80 Japanese adults infected with HCV-1b.<br />Results: After 24 h of commencement of treatment, the proportion of patients with Arg70 and Leu91 substitutions in the core region who showed ≥3.0 log drop in HCV RNA level was significantly higher than that of patients with Gln70 (His70) and/or Met91. At 8 and 12 weeks, HCV RNA loss rate of patients with rs8099917 genotype TT near IL28B gene was significantly higher than that of patients with non-TT. Multivariate analysis identified substitution of aa 70 and 91 as a predictor of ≥3.0 log fall in HCV RNA level at 24 h (Arg70 and Leu91) and SVR (Arg70), and rs8099917 (TT) as a predictor of HCV RNA loss at 12 weeks and SVR.<br />Conclusions: This study identified genetic variation near IL28B gene and aa substitution of the core region as predictors of viral dynamics during triple therapy.<br /> (Copyright © 2012 S. Karger AG, Basel.)
- Subjects :
- Adult
Aged
Amino Acid Substitution
Female
Genetic Variation
Genotype
Hepatitis C drug therapy
Humans
Interferon alpha-2
Interferon-alpha therapeutic use
Interferons
Male
Middle Aged
Oligopeptides therapeutic use
Polyethylene Glycols therapeutic use
RNA, Viral genetics
Recombinant Proteins therapeutic use
Ribavirin therapeutic use
Treatment Outcome
Young Adult
Antiviral Agents therapeutic use
Hepacivirus drug effects
Hepacivirus genetics
Interleukins genetics
Viral Core Proteins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1423-0100
- Volume :
- 55
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Intervirology
- Publication Type :
- Academic Journal
- Accession number :
- 21325786
- Full Text :
- https://doi.org/10.1159/000323526