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CD4+CD28 null T lymphocytes are expanded in young women with polycystic ovary syndrome.
- Source :
-
Fertility and sterility [Fertil Steril] 2011 Jun 30; Vol. 95 (8), pp. 2651-4. Date of Electronic Publication: 2011 Feb 16. - Publication Year :
- 2011
-
Abstract
- Women affected by polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease. We demonstrated that women with PCOS showed an expansion of CD4(+)CD28(null) T cells, an aggressive population of T lymphocytes that has been recently associated with recurrent coronary instability and type 2 diabetes mellitus. This sheds new light on possible mechanisms responsible for the higher rate of cardiovascular disease among women with PCOS.<br /> (Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adolescent
Adult
Analysis of Variance
Biomarkers blood
C-Reactive Protein analysis
Case-Control Studies
Female
Humans
Hyperinsulinism immunology
Inflammation Mediators blood
Italy
Linear Models
Polycystic Ovary Syndrome complications
Risk Assessment
Risk Factors
Young Adult
CD28 Antigens metabolism
CD4-Positive T-Lymphocytes immunology
Cardiovascular Diseases immunology
Cell Proliferation
Polycystic Ovary Syndrome immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1556-5653
- Volume :
- 95
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Fertility and sterility
- Publication Type :
- Academic Journal
- Accession number :
- 21324454
- Full Text :
- https://doi.org/10.1016/j.fertnstert.2011.01.129