CD4+CD25+ regulatory T cell-mediated changes in the expression of endocytic receptors and endocytosis process of human dendritic cells.

Authors :: Navarrete AM
Delignat S
Teillaud JL
Kaveri SV
Lacroix-Desmazes S
Bayry J
Source :: Vaccine [Vaccine] 2011 Mar 24; Vol. 29 (15), pp. 2649-52. Date of Electronic Publication: 2011 Feb 23.
Publication Year :: 2011
Abstract: CD4+CD25+ regulatory T cells (Tregs) are known to inhibit immune responses to antigens. Since, the process of antigen uptake by dendritic cells (DC) is central to induction of immune responses, we analyzed the effect of Tregs on the expression of endocytic receptors on DC and its repercussion on antigen uptake. Our results demonstrate that Tregs down-regulate the expression and uptake of antigens via C-type lectin-like receptors CD206 and DC-SIGN, restrain the pinocytosis process of DC and augment the expression of FcγRIIB, an inhibitory Fcγ receptor the engagement of which by IgG-bound antigens leads to inhibition of DC activation. Our results thus provide an additional insight on the pertinence of strategies aimed at blocking Treg functions towards improved vaccination protocols.<br /> (Copyright © 2011 Elsevier Ltd. All rights reserved.)

Subjects :: CD4-Positive T-Lymphocytes chemistry
Cell Adhesion Molecules analysis
Cells, Cultured
Humans
Interleukin-2 Receptor alpha Subunit analysis
Lectins, C-Type analysis
Mannose Receptor
Mannose-Binding Lectins analysis
Receptors, Cell Surface analysis
Receptors, IgG analysis
T-Lymphocytes, Regulatory chemistry
CD4-Positive T-Lymphocytes immunology
Dendritic Cells immunology
Endocytosis
T-Lymphocytes, Regulatory immunology

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