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Proliferation of circulating T-cells.
- Source :
-
Methods in molecular medicine [Methods Mol Med] 2000; Vol. 44, pp. 121-32. - Publication Year :
- 2000
-
Abstract
- Together with B-lymphocytes, T-lymphocytes (or T-cells) comprise the antigen (Ag)-specific arm of the immune response. The Ag receptors of both cell types are generated by recombination of multiple gene segments (1), giving rise to a large repertoire of receptors of differing specificity. When a lymphocyte encounters Ag, cellular activation occurs via aggregation of cell surface Ag receptors (2). The consequences of activation are numerous, but, in the case of the T-cell, include clonal expansion, via proliferation, and also secretion of soluble mediators and growth factors, such as interleukin-2 (for a review of the role of the T-lymphocyte in allergic disease, see ref. 3).
Details
- Language :
- English
- ISSN :
- 1543-1894
- Volume :
- 44
- Database :
- MEDLINE
- Journal :
- Methods in molecular medicine
- Publication Type :
- Academic Journal
- Accession number :
- 21312126
- Full Text :
- https://doi.org/10.1385/1-59259-072-1:121