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Pseudo-halide derivatives of titanocene: synthesis and cytotoxicity studies.
- Source :
-
Metallomics : integrated biometal science [Metallomics] 2009 Nov; Vol. 1 (6), pp. 511-7. Date of Electronic Publication: 2009 Sep 02. - Publication Year :
- 2009
-
Abstract
- The well-known anticancer drug candidate bis-[(p-methoxybenzyl)cyclopentadienyl] titanium(IV) dichloride (Titanocene ) was reacted with sodium azide or potassium cyanate, thiocyanate or selenocyanate in order to give pseudo-halide analogues of Titanocene . and were characterised by single crystal X-ray diffraction, which confirmed the expected nitrogen binding of the cyanate and thiocyanate to the titanium centre. All four titanocenes had their cytotoxicity investigated through preliminary in vitro testing on the LLC-PK (pig kidney epithelial) cell line in an MTT based assay in order to determine their IC50 values. Titanocenes were found to have IC50 values of 24 (± 8) μM, 101 (± 14) μM, 54 (± 21) μM and 27 (± 4) μM respectively. All four titanocene derivatives show significant cytotoxicity improvement when compared to unsubstituted titanocene dichloride and and showed similiar cytotoxic behaviour to Titanocene in vitro.
- Subjects :
- Animals
Cell Line
Cyanates chemistry
Inhibitory Concentration 50
Models, Molecular
Organometallic Compounds chemical synthesis
Selenium Compounds chemistry
Sodium Azide chemistry
Swine
Thiocyanates chemistry
Titanium chemistry
X-Ray Diffraction
Cell Survival drug effects
Organometallic Compounds chemistry
Organometallic Compounds toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1756-591X
- Volume :
- 1
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Metallomics : integrated biometal science
- Publication Type :
- Academic Journal
- Accession number :
- 21305159
- Full Text :
- https://doi.org/10.1039/b911753a