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[Efficacy of naftopidil in patients with overactive bladder associated with benign prostatic hyperplasia: prospective randomized controlled study to compare differences in efficacy between morning and evening medication].
- Source :
-
Hinyokika kiyo. Acta urologica Japonica [Hinyokika Kiyo] 2011 Jan; Vol. 57 (1), pp. 7-13. - Publication Year :
- 2011
-
Abstract
- A total of 100 patients with benign prostatic hyperplasia (BPH) and overactive bladder (OAB) symptoms (BPH/OAB), enrolled between June 2006 to March 2008, were randomly divided into 2 groups of morning medication (M) and evening medication (E) groups, then 50 mg of naftopidil was given once a day after breakfast or supper for 8 weeks. Data were available for efficacy analysis on 80 patients (M group ; 43, E group ; 37). Naftopidil significantly improved the overall international prostatic symptom score ; from 19.2±7.9 to 11.7±5.8 in the M group and from 19.4±6.4 to 12.3±6.8 in the E group (p<0.0001), QOL score from 4.9±0.8 to 3.2±1.4 in the M group and from 5.0±0.8 to 3.6±1.3 in the E group (p<0.0001), and OAB symptom score from 7.8±2.6 to 5.0±2.5 in the M group (p<0.0001) and from 8.6±2.9 to 5.8± 3.3 in the E group (p<0.0001). There was no significant difference in the incidence of adverse effects between the M group (6.1%) and E group (2.2%). These results suggest that naftopidil improves storage symptoms as well as voiding symptoms regardless of timing of administration.
- Subjects :
- Adrenergic alpha-Antagonists adverse effects
Aged
Aged, 80 and over
Drug Administration Schedule
Humans
Male
Middle Aged
Naphthalenes adverse effects
Piperazines adverse effects
Prostatic Hyperplasia complications
Urinary Bladder, Overactive etiology
Adrenergic alpha-Antagonists administration & dosage
Naphthalenes administration & dosage
Piperazines administration & dosage
Prostatic Hyperplasia drug therapy
Urinary Bladder, Overactive drug therapy
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0018-1994
- Volume :
- 57
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Hinyokika kiyo. Acta urologica Japonica
- Publication Type :
- Academic Journal
- Accession number :
- 21304253