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The impact of HIV drug resistance testing on changes to treatment.
- Source :
-
AIDS (London, England) [AIDS] 2011 Mar 13; Vol. 25 (5), pp. 603-10. - Publication Year :
- 2011
-
Abstract
- Background: We investigate changes made to therapy after a resistance test result and identify factors associated with switching regimen.<br />Methods: Patients receiving antiretroviral therapy (ART) who had a resistance test performed during 1998-2007 were included in the analysis. A switch was defined as starting at least two drugs/starting a drug from a class not previously experienced within 4 months of the resistance test result. Logistic regression was used to identify factors independently associated with switching regimen.<br />Results: Of the 5123 test results included in the analyses, 1874 (36.6%) were followed by a switch within 4 months of the test result. Independent factors associated with switching included genotypic sensitivity score (GSS) of the current regimen [odds ratio (OR) 4.86, 95% confidence interval (CI) 3.95, 5.97 for GSS less than 1 compared to GSS of at least 3] and a higher number of previous failures [1.12 (1.06, 1.18) per additional failed regimen]. Patients with fewer drug options were less likely to switch [0.36 (0.27, 0.48) comparing 0-3 drug options with ≥10 drug options].<br />Conclusions: Only 37% of patients switched regimen within 4 months of the resistance test result. Whilst toxicity concerns of available drugs may somewhat explain this finding, it is also likely that there is a lack of treatment options available for patients who did not switch.
- Subjects :
- Adult
Data Collection
Drug Administration Schedule
Female
Genotype
HIV Infections drug therapy
HIV Infections virology
HIV-1 genetics
Humans
Male
Microbial Sensitivity Tests
Treatment Outcome
Viral Load
Anti-Retroviral Agents administration & dosage
Drug Resistance, Viral drug effects
Drug Resistance, Viral genetics
HIV Infections genetics
HIV-1 drug effects
Retreatment
Subjects
Details
- Language :
- English
- ISSN :
- 1473-5571
- Volume :
- 25
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- AIDS (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 21297420
- Full Text :
- https://doi.org/10.1097/QAD.0b013e32834403a0