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Ultrasensitivity and positive feedback to promote sharp mitotic entry.
- Source :
-
Molecular cell [Mol Cell] 2011 Feb 04; Vol. 41 (3), pp. 243-4. - Publication Year :
- 2011
-
Abstract
- In this issue, Trunnell et al. (2011) show that in mitotic entry the positive feedback that drives the activation of cyclin-dependent kinase (Cdk) involves a very ultrasensitive step of phosphorylation of Cdc25C by Cdk, thus strongly contributing to the switch-like behavior of this essential cell-cycle transition.<br /> (Copyright © 2011 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1097-4164
- Volume :
- 41
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Molecular cell
- Publication Type :
- Academic Journal
- Accession number :
- 21292155
- Full Text :
- https://doi.org/10.1016/j.molcel.2011.01.016