Back to Search
Start Over
Synthesis and anti-hepatitis B virus activity of a novel class of thiazolylbenzimidazole derivatives.
- Source :
-
Archiv der Pharmazie [Arch Pharm (Weinheim)] 2011 Feb; Vol. 344 (2), pp. 78-83. Date of Electronic Publication: 2010 Dec 22. - Publication Year :
- 2011
-
Abstract
- Recently, heterocyclic benzimidazole derivatives have been investigated and validated as a promising class of antiviral agents. In this paper, a series of novel thiazolylbenzimidazole derivatives was synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity on the HepG2.2.15 cell line. Afterwards, the preliminary structure-activity relationship (SAR) was discussed. Compound 8b, with IC(50) = 1.1 µM and SI > 90.9, was the most promising compound and could be selected as a benchmark compound for further investigation.<br /> (Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Antiviral Agents chemistry
Antiviral Agents toxicity
Benzimidazoles chemistry
Benzimidazoles toxicity
Cell Death drug effects
Drug Screening Assays, Antitumor methods
Hep G2 Cells drug effects
Humans
Inhibitory Concentration 50
Microbial Sensitivity Tests methods
Molecular Structure
Structure-Activity Relationship
Antiviral Agents chemical synthesis
Antiviral Agents pharmacology
Benzimidazoles chemical synthesis
Benzimidazoles pharmacology
Hepatitis B virus drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1521-4184
- Volume :
- 344
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Archiv der Pharmazie
- Publication Type :
- Academic Journal
- Accession number :
- 21290423
- Full Text :
- https://doi.org/10.1002/ardp.201000167