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Mesenteric venous thrombosis in a child with type 2 protein S deficiency.
- Source :
-
Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2011 Mar; Vol. 33 (2), pp. 141-3. - Publication Year :
- 2011
-
Abstract
- A 5-year-old girl presented with abdominal pain and bloody stools 2 weeks after suffering from influenza A infection. Enhanced computed tomographic scan showed widespread splanchnic venous thrombosis and small intestine necrosis. She recovered after the necrotic bowel was resected. The patient continues to receive anticoagulant therapy. Thrombophilia screening after the complete resolution consistently showed mildly decreased protein S (PS) activity with normal PS antigen levels. Sequence analysis detected a heterozygous K196E mutation in the PROS1 gene. Type 2 PS deficiency was diagnosed. This is the first report of mesenteric vein thrombosis in a child with a type 2 PS deficiency.
- Subjects :
- Antiviral Agents therapeutic use
Blood Proteins genetics
Child, Preschool
Female
Humans
Influenza A virus
Influenza, Human complications
Influenza, Human drug therapy
Intestines blood supply
Intestines surgery
Ischemia genetics
Ischemia surgery
Mesenteric Vascular Occlusion surgery
Mutation
Oseltamivir therapeutic use
Protein S
Protein S Deficiency genetics
Venous Thrombosis surgery
Mesenteric Vascular Occlusion genetics
Protein S Deficiency complications
Venous Thrombosis genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1536-3678
- Volume :
- 33
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of pediatric hematology/oncology
- Publication Type :
- Academic Journal
- Accession number :
- 21285903
- Full Text :
- https://doi.org/10.1097/MPH.0b013e3181fce4d4