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Fatigue in multiple sclerosis is closely related to sleep disorders: a polysomnographic cross-sectional study.
- Source :
-
Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] 2011 May; Vol. 17 (5), pp. 613-22. Date of Electronic Publication: 2011 Jan 28. - Publication Year :
- 2011
-
Abstract
- Background: Sleep disorders can cause tiredness. The relationship between sleep disorders and fatigue in patients with multiple sclerosis (MS) has not yet been investigated systematically.<br />Objective: To investigate the relationship between fatigue and sleep disorders in patients with MS.<br />Methods: Some 66 MS patients 20 to 66 years old were studied by overnight polysomnography. Using a cut-off point of 45 in the Modified Fatigue Impact Scale (MFIS), the entire cohort was stratified into a fatigued MS subgroup (n=26) and a non-fatigued MS subgroup (n=40).<br />Results: Of the fatigued MS patients, 96% (n=25) were suffering from a relevant sleep disorder, along with 60% of the non-fatigued MS patients (n=24) (p=0.001). Sleep-related breathing disorders were more frequent in the fatigued MS patients (27%) than in the non-fatigued MS patients (2.5%). Significantly higher MFIS values were detected in all (fatigued and non-fatigued) patients with relevant sleep disorders (mean MFIS 42.8; SD 18.3) than in patients without relevant sleep disorders (mean MFIS 20.5; SD 17.0) (p<0.001). Suffering from a sleep disorder was associated with an increased risk of fatigue in MS (odds ratio: 18.5; 95% CI 1.6-208; p=0.018).<br />Conclusion: Our results demonstrate a clear and significant relationship between fatigue and sleep disorders.
- Subjects :
- Adult
Aged
Cross-Sectional Studies
Fatigue diagnosis
Fatigue physiopathology
Female
Germany
Humans
Logistic Models
Male
Middle Aged
Multiple Sclerosis diagnosis
Multiple Sclerosis physiopathology
Odds Ratio
Risk Assessment
Risk Factors
Sleep Wake Disorders diagnosis
Sleep Wake Disorders physiopathology
Surveys and Questionnaires
Young Adult
Fatigue etiology
Multiple Sclerosis complications
Polysomnography
Sleep
Sleep Wake Disorders complications
Subjects
Details
- Language :
- English
- ISSN :
- 1477-0970
- Volume :
- 17
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Multiple sclerosis (Houndmills, Basingstoke, England)
- Publication Type :
- Academic Journal
- Accession number :
- 21278050
- Full Text :
- https://doi.org/10.1177/1352458510393772