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Rapid pneumococcal evolution in response to clinical interventions.
- Source :
-
Science (New York, N.Y.) [Science] 2011 Jan 28; Vol. 331 (6016), pp. 430-4. - Publication Year :
- 2011
-
Abstract
- Epidemiological studies of the naturally transformable bacterial pathogen Streptococcus pneumoniae have previously been confounded by high rates of recombination. Sequencing 240 isolates of the PMEN1 (Spain(23F)-1) multidrug-resistant lineage enabled base substitutions to be distinguished from polymorphisms arising through horizontal sequence transfer. More than 700 recombinations were detected, with genes encoding major antigens frequently affected. Among these were 10 capsule-switching events, one of which accompanied a population shift as vaccine-escape serotype 19A isolates emerged in the USA after the introduction of the conjugate polysaccharide vaccine. The evolution of resistance to fluoroquinolones, rifampicin, and macrolides was observed to occur on multiple occasions. This study details how genomic plasticity within lineages of recombinogenic bacteria can permit adaptation to clinical interventions over remarkably short time scales.
- Subjects :
- Adaptation, Physiological
Anti-Bacterial Agents pharmacology
Antigenic Variation
DNA Transposable Elements
Drug Resistance, Multiple, Bacterial
Genome, Bacterial
Humans
Molecular Epidemiology
Phylogeny
Phylogeography
Pneumococcal Infections drug therapy
Pneumococcal Vaccines immunology
Polymorphism, Single Nucleotide
Prophages genetics
Selection, Genetic
Serotyping
Streptococcus Phages genetics
Streptococcus pneumoniae classification
Streptococcus pneumoniae drug effects
Streptococcus pneumoniae immunology
Evolution, Molecular
Pneumococcal Infections microbiology
Recombination, Genetic
Streptococcus pneumoniae genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9203
- Volume :
- 331
- Issue :
- 6016
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 21273480
- Full Text :
- https://doi.org/10.1126/science.1198545