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Successful pregnancy with preimplantation genetic diagnosis in a woman with mosaic Turner syndrome.
- Source :
-
Fertility and sterility [Fertil Steril] 2011 Apr; Vol. 95 (5), pp. 1788.e1-3. Date of Electronic Publication: 2011 Jan 26. - Publication Year :
- 2011
-
Abstract
- Objective: To determine the efficacy of the preimplantation cytogenetic analysis of the embryos obtained from patient with mosaic Turner syndrome before an IVF program.<br />Design: Prospective cytogenetic analysis.<br />Setting: University-based tertiary medical center.<br />Patient(s): A 29 year-old female, a partner in a couple with male factor infertility, was diagnosed with mosaic Turner syndrome with a 45,X [17]/46,XX [13] karyotype.<br />Intervention(s): Preimplantation genetic diagnosis was performed on four blastomeres obtained from four different embryos by fluorescence in situ hybridization probes specific to chromosomes X, Y, 13, 18, 21 in an intracytoplasmic sperm injection cycle.<br />Main Outcome Measure(s): Blastomeres with normal signals.<br />Result(s): Two blastomeres detected as normal were transferred and pregnancy was achieved.<br />Conclusion(s): Preimplantation Genetic Diagnose should be considered in the infertility treatment of the patient with mosaic Turner Syndrome.<br /> (Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Cytogenetic Analysis
Female
Humans
Infertility, Male complications
Male
Pregnancy
Treatment Outcome
Turner Syndrome complications
Turner Syndrome genetics
Turner Syndrome prevention & control
Fertilization in Vitro
Infertility, Male therapy
Mosaicism
Preimplantation Diagnosis methods
Turner Syndrome therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1556-5653
- Volume :
- 95
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Fertility and sterility
- Publication Type :
- Academic Journal
- Accession number :
- 21272868
- Full Text :
- https://doi.org/10.1016/j.fertnstert.2010.12.055