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Effects of oxymatrine on sympathoexcitatory reflex induced by myocardial ischemic signaling mediated by P2X₃ receptors in rat SCG and DRG.
- Source :
-
Brain research bulletin [Brain Res Bull] 2011 Apr 05; Vol. 84 (6), pp. 419-24. Date of Electronic Publication: 2011 Jan 25. - Publication Year :
- 2011
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Abstract
- Sympathoexcitatory reflex is characterized by an increase in blood pressure and sympathetic nerve activity. P2X₃ receptors in SCG neurons are involved in increasing sympathoexcitatory reflex after myocardial ischemic (MI) injury. The present study is aimed to explore the effects of oxymatrine (Oxy) on the transmission of myocardial ischemic signaling mediated by P2X₃ receptors in rat superior cervical ganglia (SCG) and cervical dorsal root ganglia (DRG) in the sympathoexcitatory reflex after myocardial ischemic injury. In this study, the expression levels of P2X₃ immunoreactivity, mRNA and protein were analyzed in SCG and DRG neurons by immunohistochemistry, in situ hybridization and Western blotting. The results show that the myocardial ischemic injury induces the increase of the systolic blood pressure and heart rate and upregulates the expression of P2X₃ receptors in SCG and DRG neurons. Upregulated expression of P2X₃ receptors in SCG and DRG neurons subsequently leads to the aggravated sympathoexcitatory reflex. Oxymatrine reduces the systolic blood pressure and heart rate in myocardial ischemic rats. After myocardial ischemic rats are treated with oxymatrine, the expression levels of P2X₃ immunoreactivity, mRNA and protein are lower than those in myocardial ischemic rats. Oxymatrine may decrease the expression of P2X₃ receptor and depress the aggravated sympathoexcitatory reflex induced by the nociceptive transmission of myocardial ischemic injury via P2X₃ receptors of rat SCG and DRG neurons.<br /> (Copyright © 2011 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Anti-Arrhythmia Agents pharmacology
Blood Pressure drug effects
Ganglia, Spinal drug effects
Heart Rate drug effects
Neurons cytology
Neurons metabolism
Norepinephrine metabolism
Random Allocation
Rats
Rats, Sprague-Dawley
Signal Transduction drug effects
Superior Cervical Ganglion drug effects
Alkaloids pharmacology
Ganglia, Spinal physiology
Myocardial Ischemia physiopathology
Quinolizines pharmacology
Receptors, Purinergic P2X3 metabolism
Reflex drug effects
Signal Transduction physiology
Superior Cervical Ganglion physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2747
- Volume :
- 84
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Brain research bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 21272621
- Full Text :
- https://doi.org/10.1016/j.brainresbull.2011.01.011