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Changes in urodynamic parameters after tolterodine treatment for female overactive bladder syndrome with or without voiding dysfunction.
- Source :
-
The journal of obstetrics and gynaecology research [J Obstet Gynaecol Res] 2011 May; Vol. 37 (5), pp. 436-41. Date of Electronic Publication: 2011 Jan 27. - Publication Year :
- 2011
-
Abstract
- Aim: To investigate changes in urodynamic parameters after tolterodine treatment for female overactive bladder syndrome, especially in patients with voiding dysfunction.<br />Methods: Between January and December 2006, 44 patients were enrolled for six months of treatment with tolterodine. Pre-treatment and post-treatment urodynamic studies were scheduled for the enrolled patients.<br />Results: Among the remaining 33 patients (11 dropped out), bladder capacity (P < 0.001) and post-void residual urine (P = 0.009) increased, and functional urethral length (P = 0.049) and pad weight test (P = 0.03) decreased after treatment. Besides this, detrusor pressure at maximal urine flow, functional urethral length, maximal urethral pressure and maximal urethral closure pressure were less affected by tolterodine in patients with voiding dysfunction, compared to those without voiding dysfunction.<br />Conclusions: Tolterodine treatment increased bladder capacity and decreased urine leakage; however, some urodynamic parameters in patients with voiding dysfunction were less affected by tolterodine treatment.<br /> (© 2011 The Authors. Journal of Obstetrics and Gynaecology Research © 2011 Japan Society of Obstetrics and Gynecology.)
- Subjects :
- Adult
Aged
Female
Humans
Middle Aged
Tolterodine Tartrate
Treatment Outcome
Urinary Bladder, Overactive complications
Urinary Bladder, Overactive physiopathology
Urination Disorders physiopathology
Urodynamics
Benzhydryl Compounds administration & dosage
Cresols administration & dosage
Muscarinic Antagonists administration & dosage
Phenylpropanolamine administration & dosage
Urinary Bladder, Overactive drug therapy
Urination Disorders complications
Subjects
Details
- Language :
- English
- ISSN :
- 1447-0756
- Volume :
- 37
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The journal of obstetrics and gynaecology research
- Publication Type :
- Academic Journal
- Accession number :
- 21272154
- Full Text :
- https://doi.org/10.1111/j.1447-0756.2010.01370.x