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Targeting focal adhesion kinase in neuroblastoma.

Authors :
Gillory L
Beierle EA
Source :
Anti-cancer agents in medicinal chemistry [Anticancer Agents Med Chem] 2010 Dec; Vol. 10 (10), pp. 714-21.
Publication Year :
2010

Abstract

Neuroblastoma is the most common extracranial solid tumor encountered in children, and continues to carry a dismal prognosis. Focal adhesion kinase (FAK) has been shown to be upregulated in a number of human tumors and is related to tumor virulence and patient prognosis. We have demonstrated FAK expression in human neuroblastoma cell lines and tumors, and have shown that FAK is important for neuroblastoma tumor cell viability. We have also demonstrated that FAK inhibition through a number of different methods results in decreased neuroblastoma survival both in vitro and in vivo. The current review addresses the merit of further exploring FAK inhibition as a novel treatment for neuroblastoma.

Details

Language :
English
ISSN :
1875-5992
Volume :
10
Issue :
10
Database :
MEDLINE
Journal :
Anti-cancer agents in medicinal chemistry
Publication Type :
Academic Journal
Accession number :
21269252
Full Text :
https://doi.org/10.2174/187152010794728684