Back to Search
Start Over
Targeting focal adhesion kinase in neuroblastoma.
- Source :
-
Anti-cancer agents in medicinal chemistry [Anticancer Agents Med Chem] 2010 Dec; Vol. 10 (10), pp. 714-21. - Publication Year :
- 2010
-
Abstract
- Neuroblastoma is the most common extracranial solid tumor encountered in children, and continues to carry a dismal prognosis. Focal adhesion kinase (FAK) has been shown to be upregulated in a number of human tumors and is related to tumor virulence and patient prognosis. We have demonstrated FAK expression in human neuroblastoma cell lines and tumors, and have shown that FAK is important for neuroblastoma tumor cell viability. We have also demonstrated that FAK inhibition through a number of different methods results in decreased neuroblastoma survival both in vitro and in vivo. The current review addresses the merit of further exploring FAK inhibition as a novel treatment for neuroblastoma.
- Subjects :
- Animals
Antineoplastic Agents pharmacology
Humans
Protein Kinase Inhibitors pharmacology
Antineoplastic Agents therapeutic use
Focal Adhesion Protein-Tyrosine Kinases antagonists & inhibitors
Focal Adhesion Protein-Tyrosine Kinases metabolism
Neuroblastoma drug therapy
Neuroblastoma enzymology
Protein Kinase Inhibitors therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1875-5992
- Volume :
- 10
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Anti-cancer agents in medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 21269252
- Full Text :
- https://doi.org/10.2174/187152010794728684