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Plasma reactive carbonyl species levels and risk of non-alcoholic fatty liver disease.
- Source :
-
Journal of gastroenterology and hepatology [J Gastroenterol Hepatol] 2011 Jun; Vol. 26 (6), pp. 1010-5. - Publication Year :
- 2011
-
Abstract
- Background and Aim: Oxidative stress plays a critical role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). However, there is still no large cohort study to explore the direct risk role of oxidative stress for NAFLD. This study is to test the hypothesis that elevated oxidative stress is a direct risk factor for the pathogenesis of NAFLD under controlling the potential effects of covariates.<br />Methods: The levels of serum cholesterol, serum triglyceride, fasting plasma glucose and plasma reactive carbonyl species (RCS) were measured from 1204 Chinese Han adults, and the questionnaire and physical examination were administered to those with known and suspected risk factors for NAFLD.<br />Results: Statistically significant high levels of blood pressure, fasting plasma glucose, serum cholesterol and triglyceride, body mass index, serum alanine aminotransferase and aspartate aminotransferase, and plasma RCS were observed in NAFLD subjects compared to healthy subjects (P < 0.01). Multivariate-adjusted odds ratio illustrated that, compared with the lowest quartile of plasma RCS levels, the highest quartile subjects had a 132% increase in the risk of developing NAFLD. Further results from multi-interaction analysis demonstrated that the underlying mechanism of the risk of NAFLD by unhealthy physical conditions and lifestyles might be, at least in part, through the oxidative stress.<br />Conclusions: Our findings provide credible evidence from a large population that oxidative stress, as indicated by plasma RCS levels, may be a direct risk factor for developing NAFLD.<br /> (© 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.)
- Subjects :
- Adult
Alanine Transaminase blood
Analysis of Variance
Aspartate Aminotransferases blood
Biomarkers blood
Blood Glucose analysis
Blood Pressure
Body Mass Index
Case-Control Studies
China
Cholesterol blood
Fatty Liver blood
Fatty Liver etiology
Fatty Liver physiopathology
Female
Humans
Logistic Models
Male
Middle Aged
Non-alcoholic Fatty Liver Disease
Odds Ratio
Physical Examination
Risk Assessment
Risk Factors
Surveys and Questionnaires
Triglycerides blood
Up-Regulation
Oxidative Stress
Thiobarbituric Acid Reactive Substances metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1440-1746
- Volume :
- 26
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of gastroenterology and hepatology
- Publication Type :
- Academic Journal
- Accession number :
- 21265881
- Full Text :
- https://doi.org/10.1111/j.1440-1746.2011.06672.x