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Increasing rates of gastroenteritis hospital discharges in US adults and the contribution of norovirus, 1996-2007.
- Source :
-
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2011 Feb 15; Vol. 52 (4), pp. 466-74. Date of Electronic Publication: 2011 Jan 22. - Publication Year :
- 2011
-
Abstract
- Background: Diarrhea remains an important cause of morbidity, but until the mid 1990s, hospital admissions for diarrhea in the US adult population were declining. We aimed to describe recent trends in gastroenteritis hospitalizations and to determine the contribution of norovirus.<br />Methods: We analyzed all gastroenteritis-associated hospital discharges during 1996-2007 from a nationally representative data set of hospital inpatient stays. Annual rates of discharges by age were calculated. Time-series regression models were fitted using cause-specified discharges as explanatory variables; model residuals were analyzed to estimate norovirus- and rotavirus-associated discharges. We then calculated the annual hospital charges for norovirus-associated discharges.<br />Results: Sixty-nine percent of all gastroenteritis discharges were cause-unspecified and rates increased by ≥ 50% in all adult and elderly age groups (≥ 18 years of age) from 1996 through 2007. We estimate an annual mean of 71,000 norovirus-associated hospitalizations, costing $493 million per year, with surges to nearly 110,000 hospitalizations per year in epidemic seasons. We also estimate 24,000 rotavirus hospitalizations annually among individuals aged ≥ 5 years.<br />Conclusions: Gastroenteritis hospitalizations are increasing, and we estimate that norovirus is the cause of 10% of cause-unspecified and 7% of all-cause gastroenteritis discharges. Norovirus should be routinely considered as a cause of gastroenteritis hospitalization.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Caliciviridae Infections pathology
Child
Child, Preschool
Female
Gastroenteritis pathology
Hospitalization statistics & numerical data
Humans
Infant
Infant, Newborn
Male
Middle Aged
Prevalence
United States epidemiology
Young Adult
Caliciviridae Infections epidemiology
Caliciviridae Infections virology
Gastroenteritis epidemiology
Gastroenteritis virology
Norovirus isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6591
- Volume :
- 52
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
- Publication Type :
- Academic Journal
- Accession number :
- 21258098
- Full Text :
- https://doi.org/10.1093/cid/ciq163