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Kinetics of p24 antigenemia, IgM, IgG antibodies to p24 and p41 and Ig virus isolation in rabbits experimentally infected with HIV-1.
- Source :
-
Microbiologica [Microbiologica] 1990 Jul; Vol. 13 (3), pp. 215-24. - Publication Year :
- 1990
-
Abstract
- In rabbits experimentally infected with 1.10(5) u.i./ml HIV, IgM antibodies were detected 10-15 days after infection, reaching peak value two weeks later and remaining stable for two weeks long. Then a the IgM serotiters progressively decreased and were negative at ten weeks. HIV p24 antigen was detected ten-fifteen days after infection, reaching peak value five-six weeks later. Antigenemia subsequently decreased and reached a second peak after nine weeks. In our experimental conditions, the antigenemia persisted throughout the observation period. The IgG antibody titer reached a maximum two weeks after infection; the time course showed a decrease after ten weeks, followed by progressively decreasing fluctuating course. After twenty four weeks of infection the serotiter values though lower were always positive. Three-four weeks after infection we detected IgG antibodies to the major core protein p24. Reactivity of IgG antibodies to gp41 was observed earlier than reactivity to p24; these antibodies were detected over six months after infection. Viruses indistinguishable from HIV were isolated from the peripheral blood mononuclear cells of infected rabbits 30, 60 and 180 days after infection. These data further confirm that the rabbit may serve as an economical and reproducible model for HIV infection in which vaccines and antiviral agents could be tested.
- Subjects :
- Animals
Disease Models, Animal
Gene Products, gag immunology
HIV Antigens blood
HIV Core Protein p24
HIV Envelope Protein gp41 immunology
HIV Infections microbiology
HIV-1 immunology
HIV-1 ultrastructure
Immunoglobulin G biosynthesis
Immunoglobulin M biosynthesis
Kinetics
Microscopy, Electron
Rabbits
Viral Core Proteins immunology
Virion isolation & purification
Virion ultrastructure
Gene Products, gag blood
HIV Antibodies biosynthesis
HIV Antigens immunology
HIV Infections immunology
HIV-1 isolation & purification
Viral Core Proteins blood
Subjects
Details
- Language :
- English
- ISSN :
- 0391-5352
- Volume :
- 13
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Microbiologica
- Publication Type :
- Academic Journal
- Accession number :
- 2125683