Back to Search Start Over

Rates of anti-tuberculosis drug resistance in Kampala-Uganda are low and not associated with HIV infection.

Authors :
Lukoye D
Cobelens FG
Ezati N
Kirimunda S
Adatu FE
Lule JK
Nuwaha F
Joloba ML
Source :
PloS one [PLoS One] 2011 Jan 10; Vol. 6 (1), pp. e16130. Date of Electronic Publication: 2011 Jan 10.
Publication Year :
2011

Abstract

Background: Drug resistance among tuberculosis patients in sub-Saharan Africa is increasing, possibly due to association with HIV infection. We studied drug resistance and HIV infection in a representative sample of 533 smear-positive tuberculosis patients diagnosed in Kampala, Uganda.<br />Methods/principal Findings: Among 473 new patients, multidrug resistance was found in 5 (1.1%, 95% CI 0.3-2.5) and resistance to any drug in 57 (12.1%, 9.3-15.3). Among 60 previously treated patients this was 7 (11.7%, 4.8-22.6) and 17 (28.3%; 17.5-41.4), respectively. Of 517 patients with HIV results, 165 (31.9%, 27.9-36.1) tested positive. Neither multidrug (adjusted odds ratio (OR(adj)) 0.7; 95% CI 0.19-2.6) nor any resistance (OR(adj) 0.7; 0.43-1.3) was associated with HIV status. Primary resistance to any drug was more common among patients who had worked in health care (OR(adj) 3.5; 1.0-12.0).<br />Conclusion/significance: Anti-tuberculosis drug resistance rates in Kampala are low and not associated with HIV infection, but may be associated with exposure during health care.

Details

Language :
English
ISSN :
1932-6203
Volume :
6
Issue :
1
Database :
MEDLINE
Journal :
PloS one
Publication Type :
Academic Journal
Accession number :
21249225
Full Text :
https://doi.org/10.1371/journal.pone.0016130