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Relation of circulating osteoprotegerin levels on admission to microvascular obstruction after primary percutaneous coronary intervention.
- Source :
-
The American journal of cardiology [Am J Cardiol] 2011 Mar 15; Vol. 107 (6), pp. 857-62. Date of Electronic Publication: 2011 Jan 19. - Publication Year :
- 2011
-
Abstract
- Osteoprotegerin (OPG), a soluble member of the tumor necrosis factor receptor superfamily, has recently been linked to atherosclerosis and development of postinfarction heart failure. This study was designed to assess the association between admission OPG levels and microvascular obstruction (MVO) in patients who underwent primary percutaneous coronary intervention (p-PCI). Plasma samples for OPG analysis were obtained <30 minutes after admission in 47 patients who underwent p-PCI. Angiographic no-reflow (Thrombolysis In Myocardial Infarction [TIMI] flow grade <3 or 3 with myocardial blush grade 0 or 1 after p-PCI) was assessed immediately after p-PCI. MVO was assessed and quantified by the intracoronary hemodynamic measure of index of microcirculatory resistance performed on day 4 or 5 after p-PCI. Patients with angiographic no-reflow had significantly higher OPG levels on admission. On multiple linear regression analysis, OPG (β = 0.412, p = 0.001) and B-type natriuretic peptide (β = 0.409, p = 0.001) levels were independently and directly associated with the index of microcirculatory resistance. In conclusion, plasma OPG levels on admission are strongly associated with MVO and significantly correlated with the degree of MVO after p-PCI. It remains to be established whether improvement of microvascular perfusion is feasible with therapeutic strategies aimed to decrease circulating OPG levels.<br /> (Copyright © 2011 Elsevier Inc. All rights reserved.)
- Subjects :
- Biomarkers blood
Chi-Square Distribution
Coronary Angiography
Coronary Circulation
Female
Humans
Linear Models
Male
Microcirculation
Middle Aged
Myocardial Infarction diagnostic imaging
Platelet Aggregation Inhibitors administration & dosage
Prospective Studies
Statistics, Nonparametric
Angioplasty, Balloon, Coronary
Myocardial Infarction blood
Myocardial Infarction therapy
Osteoprotegerin blood
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1913
- Volume :
- 107
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The American journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 21247537
- Full Text :
- https://doi.org/10.1016/j.amjcard.2010.10.071