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P-selectin antagonism in inflammatory disease.
- Source :
-
Current pharmaceutical design [Curr Pharm Des] 2010; Vol. 16 (37), pp. 4113-8. - Publication Year :
- 2010
-
Abstract
- Inflammation plays a fundamental role in many chronic diseases, including atherosclerosis associated cardiovascular disease. Adhesion of immune cells plays a critical role in the inflammatory response and indeed the pathophysiology of inflammatory related diseases. P-selectin is an inflammatory adhesion molecule, enabling the recruitment of leukocytes to the endothelium and to activated platelets involved with the growing thrombus. P-selectin is critical in the progression of atherosclerosis as evidenced by knockout animal models where P-selectin knockout mice crossed with apoE deficient mice exhibit significantly reduced atherosclerosis and leukocyte recruitment in the plaque. A soluble form of P-selectin also exists, which may have pro-atherogenic and pro-thrombotic effects. Thus targeting of P-selectin remains a strong clinical candidate for developing novel therapeutic strategies in inflammatory diseases. This review will discuss the role of P-selectin and describe the function of P-selectin antagonists as clinical targets.
- Subjects :
- Animals
Atherosclerosis drug therapy
Atherosclerosis immunology
Atherosclerosis physiopathology
Disease Progression
Humans
Inflammation drug therapy
Inflammation physiopathology
Leukocytes immunology
Leukocytes physiology
Membrane Glycoproteins immunology
Membrane Glycoproteins metabolism
Mice
Mice, Knockout
Molecular Targeted Therapy
P-Selectin immunology
Platelet Activation
Thrombosis immunology
Thrombosis physiopathology
Inflammation immunology
P-Selectin antagonists & inhibitors
P-Selectin physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4286
- Volume :
- 16
- Issue :
- 37
- Database :
- MEDLINE
- Journal :
- Current pharmaceutical design
- Publication Type :
- Academic Journal
- Accession number :
- 21247396
- Full Text :
- https://doi.org/10.2174/138161210794519192